We are leveraging the dynamic simulation methods developed to study whole body movement to advance computational biology. Molecular dynamic simulation is currently limited by two related issues: since one typically must integrate the atomic equations of motion starting from the femtosecond timescale, atomistic simulations typically have a limited timescale (picoseconds to nanoseconds for large proteins) and include data rising from the femtosecond vibrational modes, which may be irrelevant to questions of larger scale motions. The methods we are developing address both issues: by coarse-graining and using variable step integrators, our simulations overcome the femtosecond time-step limitation, greatly speeding calculation and removing undesired fast timescale motion. Such techniques could have vast applications in numerous areas in molecular simulation.