NMBL

Biomedical Imaging

zebrascope-live-1

We develop and use advanced medical imaging techniques to determine muscle and bone geometry, measure in vivo joint and muscle motion, and characterize muscle architecture. We have designed and built an optical imaging system for capturing individual human sarcomeres from nearly any location in the body.

Related Publications

  • Chen, X., Sanchez, G.N., Schnitzer, M.J., Delp, S.L. Changes in sarcomere lengths of the human vastus lateralis muscle with knee flexion measured using in vivo microendoscopy Journal of Biomechanics, in press. Download PDF file

  • Wentland, A.L., McWalter, E.J., Pal, S., Delp, S.L. and Gold, G.E., Muscle velocity and inertial force from phase contrast MRI. Journal of Magnetic Resonance Imaging, 42(2),2015. Download PDF Document

  • Sanchez, G.N., Sinha, S., Liske, H., Chen, X., Nguyen, V., Delp, S.L., Schnitzer, M.J. In Vivo Imaging of Human Sarcomere Twitch Dynamics in Individual Motor Units. Neuron, vol 88, pp 1109-1120. Download PDF Document

  • Keenan, K.E., Besier, T.F., Pauly, J.M., Smith, R.L., Delp, S.L., Beaupre, G.S., Gold, G.E.. T1rho dispersion in articular cartilage: relationship to material properties and macromolecular content. Cartilage, 6(2), 113-122
    Download PDF Document

  • Cosgrove, B.D., Gilbert, P.M., Porpiglia, E., Mourkioti, F., Lee, S.P., Corbel, S.Y., Llewellyn, M.E., Delp, S.L., Blau, H.M. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine, vol 20, pp 255-264. Download PDF Document

  • Cromie, M.J., Sanchez, G.N., Schnitzer, M.J., Delp, S.L. Sarcomere lengths in human extensor carpi radialis brevis measured by microendoscopy. Muscle & Nerve, vol 8, pp 286-292. Download PDF Document

  • Pal, S., Besier, T.F., Beaupre, G.S., Fredericson, M., Delp, S.L., Gold, G.E. Patellar maltracking is prevalent among patellofemoral pain subjects with patella alta: an upright, weightbearing MRI study. Journal of Orthopaedic Research, vol 31, pp 448-457. Download PDF Document

  • Draper, C.E., Quon, A., Fredericson, M., Besier, T.F., Delp, S.L., Beaupre, G.S., Gold, G.E. Comparison of MRI and 18F-NaF PET/CT in patients with patellofemoral pain. Journal of Magnetic Resonance Imaging, vol 36, pp 928-932. Download PDF Document

  • Chen, C.A., Chen, W., Goodman, S.B., Hargreaves, B.A., Koch, K.M., Lu, W., Brau, A.C., Draper, C.E., Delp, S.L., Gold, G.E. New MR imaging methods for metallic implants in the knee: artifact correction and clinical impact. Journal of Magnetic Resonance Imaging, vol 33, pp 1121-1127. Download PDF Document

  • Keenan, K.E., Besier, T.F., Pauly, J.M., Han, E., Rosenberg, J., Smith, R.L., Delp, S.L., Beaupré, G.S., Gold, G.E. Prediction of glycosaminoglycan content in human cartilage by age, T1rho and T2 MRI. Osteoarthritis and Cartilage, vol 19, pp 171-179. Download PDF Document