We have performed anatomical studies to measure muscle architecture, muscle moment arms, and joint kinematics.
Murray, W. M., Buchanan, T.S., Delp, S.L. The isometric functional capacity of elbow muscles. Journal of Biomechanics, vol. 33, pp. 943-952, 2000. Download PDF Document
Strength and Coordination Measurements
We have studied the activation patterns of muscles in unimpaired subjects and in subjects with movement abnormalities by securing the limb to a load cell, asking subjects to match target loads displayed on a computer monitor, and recording the subjects’ EMG.
We created and evaluated computer-integrated instrumentation that incorporates highly accurate measurement devices to locate joint centers, track surgical tools, and align prosthetic components.
Delp, S.L., Loan, J.P., Basdogan, C., Rosen, J.M. Surgical simulation: an emerging technology for emergency medical training. Presence: Teleoperators and Virtual Environments, vol. 6, pp. 147-159, 1997. Download PDF Document
Three-Dimensional Muscle Modeling
We developed a mechanics-based formulation for representing three-dimensional skeletal muscle architecture and geometry, including a nonlinear constitutive model for muscle and tendon and graphics-based modeling techniques to characterize the three-dimensional trajectories of muscle fibers from medical image data.
Webb, J.D., Blemker, S.S., Delp, S.L. 3D finite element models of shoulder muscles for computing lines of actions and moment arms. Computer Methods in Biomechanics and Biomedical Engineering, pp 1-9. Download PDF Document
Blemker, S.S., Delp, S.L. Three-Dimensional Representation of Complex Muscle Architectures and Geometries. Annals of Biomedical Engineering, vol 33, pp. 661–673, 2005. Download PDF Document
Modeling and Simulation of Molecular Motors
We developed tools for creating course-grained geometric models of protein structures, performing molecular dynamic simulations to estimate physical properties, and running forward dynamic simulations of myosin during its power stroke.
Parker, D., Bryant, Z., Delp, S.L. Coarse-grained structural modeling of molecular motors using multibody dynamics, Cellular and Molecular Bioengineering, vol 2, pp 366-374. Download PDF Document