NMBL

Optogenetics and Neuromodulation

Optimigenetics-Nerve-Image-2

We apply optogenetics to control neural activity in the peripheral nervous system. We have achieved light-mediated activation of motor neurons to stimulate muscle contraction, and we are developing methods for inhibition of neural activity to control spasticity and pain.

Related Publications

  • Christensen, A.J., Iyer, S.M., Francois, A., Vyas, S., Ramakrishnan, C., Vesuna, S., Deisseroth, K., Scherrer, G., Delp, S.L. In vivo interrogation of spinal mechanosensory circuits. Cell Reports, 17:1699-1710, 2016. Download PDF file

  • Iyer, S.M., Vesuna, S., Ramakrishnan, C., Huynh, K., Young, S., Berndt, A., Lee, S.Y., Gorini, C.J., Deisseroth, K., Delp, S.L. Optogenetic and chemogenetic strategies for sustained inhibition of pain Scientific Reports, 6:30570 Download PDF file

  • Ferenczi E.A., Vierock J., Atsuta-Tsunoda K., Tsunoda S.P., Ramakrishnan C., Gorini C., Thompson K., Lee S.Y., Berndt A., Perry C., Minniberger S., Vogt A., Mattis J., Prakash1 R., Delp S.L., Deisseroth K., Peter Hegemann. Optogenetic approaches addressing extracellular modulation of neural excitability. Scientific reports, 6, 2016. Download PDF Document

  • Berndt A., Lee S.Y., Wietek J., Ramakrishnan C., Steinberg E.E., Rashid A.J., Kim H., Park S., Santoro A., Frankland P.W., Iyer S.M., Pak S., Ahrlund-Richter S., Delp S.L., Malenka R.C., Josselyn S.A., Carlen M., Hegemann P., Deisseroth K. Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity. Proceedings of the National Academy of Sciences, 201523341, 2015. Download PDF Document

  • Montgomery, K.L., Iyer S.M., Christensen A.J., Deisseroth K., Delp S.L. Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system. Science Translational Medicine, 8(337), 337rv5-337rv5, 2016. Download PDF Document

  • Montgomery, K.L., Yeh, A.J., Ho, J.S., Tsao, V., Iyer, S.M., Grosenick, L., Ferenczi, E.A., Tanabe, Y., Deisseroth, K., Delp, S.L., Poon, A.S.Y. Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice. Nature Methods, vol 12, pp 969-974.  Download PDF Document

  • Iyer, S.M., Delp, S.L. Optogenetic Regeneration. Science, vol 344, pp 44-45. Download PDF Document

  • Iyer, S.M., Montgomery, K.L., Towne, C., Lee, S.Y., Ramakrishnan, C., Deisseroth, K., Delp, S.L. Virally mediated optogenetic excitation and inhbition of pain in freely moving nontransgenic mice. Nature Biotechnology, vol 32, pp 274-278. Download PDF Document

  • Delp, S.L. Studying Circuits with Therapy in Mind: Therapy for the Periphery. Cell, vol 156, pp 862. Download PDF Document

  • Liske, H., Qian, X., Anikeeva, P., Deisseroth, K., Delp, S. Optical control of neuronal excitation and inhibition using a single opsin protein, ChR2. Scientific Reports, vol 3 . Download PDF Document