OpenSim Software Architect
aseth@stanford.edu
Clark Center, Room S322
Research Interests
I am interested in extracting detailed information about human movement from computer models
for the purpose of understanding form and function that leads to improved quality of treatment
and rehabilitation for movement disorders. Towards this end, I design and develop simulation
software (OpenSim) and musculoskeletal models to better represent the mechanics of individual
subjects (patients) that includes interaction with the environment (i.e. contact modeling). In order
to control these complex models, I have applied nonlinear and feedback control methods guided
by experimental data and I am currently exploring reflex control to improve the robustness of
simulations in response to perturbations. I am very excited about others using and building upon
OpenSim to pursue their research goals and for them to share their contributions with the broader
scientific community.
Degrees
Ph.D. in Biomedical Engineering, The University of Texas, 2007
M.A.Sc. in Systems Design Engineering, University of Waterloo, 2000
B.A.Sc. in Systems Design Engineering, University of Waterloo, 1997
Honors and Awards
OpenSim Fellows Founding Member, Stanford University, 2012
Simbios Distinguished Postdoctoral Fellowship, Stanford University, 2007
Andrzej J. Komor New Investigator Award. The International Society of Biomechanics Technical Group on Computer Simulation, 2005
The University of Texas Continuing Fellowship, 2004
National Science & Engineering Research Council of Canada (NSERC) Scholarship, 1997
Representative Publications
- Seth, A., Hicks J.L., Uchida, T.K., Habib, A., Dembia, C.L., Dunne, J.J., Ong, C.F., DeMers, M.S., Rajagopal, A., Millard, M., Hamner, S.R., Arnold, E.M., Yong, J.A., Lakshmikanth, S.K., Sherman,n M.A., Delp, S.L. OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement. PLOS Computational Biology, 14(7). Download PDF
- Seth A., Matias R., Veloso A.P., Delp S.L. A Biomechanical Model of the Scapulothoracic Joint to Accurately Capture Scapular Kinematics during Shoulder Movements. PLoS ONE, 11(1): e0141028, 2016. Download PDF . PloS ONE
- Uchida, T.K., Seth, A., Pouya, S., Dembia, C.L., Hicks, J.L., Delp, S.L. Simulating ideal assistive devices to reduce the metabolic cost of running. PLOS ONE, 11(9):e0163417, 2016. Download PDF
- Hicks, J.L., Uchida, T.K., Seth, A., Rajagopal, A., Delp, S.L. Is my model good enough? Best practices for verification and validation of musculoskeletal models and simulations of movement. ASME Journal of Biomechanical Engineering 137(2):020905, 2015. Download PDF
- Shermnan, M.A., Seth, A., Delp, S.L. What is a moment arm? Calculating muscle effectiveness in Biomechanical models using generalized coordinates, Proceedings of the ASME 2013 International Design Engineering Technical Conferences. Download PDF
- Hamner, S.R., Seth, A., Steele, K.M., Delp, S.L. A rolling constraint reproduces ground reaction forces and moments in dynamic simulations of walking, running, and crouch gait. Journal of Biomechanics, vol 46, pp 1772-1776 Download PDF
- Arnold, E.M., Hamner, S.R., Seth, A., Millard, M., Delp, S.L. How muscle fiber lengths and velocities affect muscle force generation as humans walk and run at different speeds. Journal of Experimental Biology, vol 216, pp 2150-2160. Download PDF
- Steele, K.M., Seth, A., Hicks, J.L., Schwartz, M.H., Delp, S.L. Muscle contributions to vertical and fore-aft accelerations are altered in subjects with crouch gait. Gait and Posture, vol 38, pp 86-91. Download PDF
- Millard, M., Uchida, T., Seth, A., Delp, S.L. Flexing computational muscle: modeling and simulation of musculotendon dynamics. ASME Journal of Biomechanical Engineering 135(2):021005, 2013. Download PDF
- John, C.T., Seth, A., Schwartz, M.H., Delp, S.L. Contributions of muscles to mediolateral ground reaction force over a range of walking speeds. Journal of Biomechanics, vol 45, pp 2438-2443. Download PDF
- Reinbolt, J.A., Seth, A., Delp, S.L. Simulation of human movement: applications using OpenSim. Procedia IUTAM, vol 2, pp 186-198. Download PDF
- Seth, A., Sherman, M.A., Reinbolt, J.A., Delp, S.L. OpenSim: a musculoskeletal modeling and simulation framework for in silico investigations and exchange. Procedia IUTAM, vol 2, pp 212-232. Download PDF
- Sherman, M.A., Seth, A., Delp, S.L. Simbody: multibody dynamics for biomedical research. Procedia IUTAM, vol 2, pp 241-261. Download PDF
- Hamner, S.R., Seth, A., Delp, S.L. Muscle contributions to propulsion and support during running, Journal of Biomechanics, vol 43, pp 2709-2716. Download PDF
- Steele, K.M., Seth, A., Hicks, J.L., Schwartz, M.S., Delp, S.L. Muscle contributions to support and progression during single-limb stance in crouch gait. Journal of Biomechanics, vol 43, pp 2099-2105. Download PDF
- Seth, A., Sherman, M., Eastman, P., Delp, S. Minimal formulation of joint motion for biomechanisms, Nonlinear Dyn, vol 62, pp 291-303. Download PDF
- Seth, A. and Pandy, M.G. A neuromusculoskeletal tracking method for estimating individual
muscle forces in human movement. Journal of Biomechanics, 40:356-366, 2007.